Polynucleotides (Rejuran)
What is Polynucleotides (Rejuran)?
Polynucleotides are short fragments of purified DNA, in Rejuran's case sourced from salmon, which are highly compatible with human skin. Injected into the skin, they act as a kind of repair signal: they hold water, calm inflammation and support the fibroblasts that make collagen. The result is a gradual improvement in skin quality rather than a filling or freezing effect.
Rejuran, made by PharmaResearch in South Korea, is the brand Dr Garara uses for this. The range covers general facial skin quality, a finer version for the delicate under-eye area, and a formulation aimed at scarring. It is sometimes called a bio-remodelling or skin-booster treatment.
Because it is injected rather than heated, it suits all skin tones. Polynucleotides work with the skin's own repair machinery rather than adding volume — improving quality, elasticity and texture over time.
At a glance
Treatment type
Injectable polynucleotide (PN) bio-remodelling
Brand used
Rejuran (PharmaResearch, South Korea)
Source
Purified polynucleotides derived from salmon DNA
How it works
PN fragments support repair, hydration and collagen
Best known for
Skin quality, elasticity, fine lines and under-eyes
Range
Rejuran for the face, a version for the under-eye area, and one for scarring
Typical course
Usually around 3 sessions, a few weeks apart
Downtime
Usually mild; small bumps or redness for a day or so
Skin types
Injectable, so suitable for all skin tones
How it works
Hydration and scaffolding: the polynucleotide gel holds water in the skin and provides a temporary scaffold that supports cells as they work.
Fibroblast support: polynucleotides encourage fibroblasts, the cells that produce collagen and elastin, improving firmness and texture over time.
Calming and repair: a soothing, antioxidant effect supports healing, which is why a version is used for scarring and post-inflammatory skin.
A regenerative, not a filling, effect: Rejuran improves the quality of the skin itself; it is not a filler and does not add structural volume.
The benefits
Improves skin quality: better hydration, elasticity and overall texture across the treated area.
Softens fine lines by supporting collagen.
Helps the under-eye area with a finer formulation for tired, crepey under-eyes.
Supports scar healing with a dedicated version.
Calms and repairs sensitised or post-inflammatory skin.
Suits every skin tone — injected rather than heated, so no pigment risk.
Concerns it treats
What to expect
Before
Consultation and assessment. Numbing cream is applied, especially for the under-eye area.
During
A series of small injections across the treatment area. Most people tolerate it well; it takes around 20 to 30 minutes.
Immediately after
Small bumps, redness or mild swelling that settle over hours to a couple of days.
Downtime
Usually mild and short-lived.
Results
Skin quality improves gradually over the weeks following each session.
Course
Commonly around three sessions a few weeks apart, then maintenance.
What the evidence shows
Skin rejuvenation
- A 2024 systematic review of nine studies in 219 patients found polynucleotide injections reduced wrinkles and improved skin texture and elasticity, with statistically significant results in several studies and generally mild, transient side effects (Lampridou et al., J Cosmet Dermatol, 2024).
- The same review noted patient satisfaction was moderate to high, while calling for more high-quality studies to confirm the best protocols.
Mechanism
- Polynucleotides and the related polydeoxyribonucleotides support fibroblast activity and extracellular-matrix components, which underpins their use in biostimulation and wound healing.
Individual results vary and depend on assessment at consultation. Manufacturer figures are attributed as such.
Key facts
- Polynucleotides are purified DNA fragments; Rejuran (PharmaResearch) is salmon-derived.
- They improve skin quality, hydration, elasticity and fine lines rather than adding volume.
- The Rejuran range includes versions for the face, the under-eye area and scarring.
- A 2024 systematic review found PN injections improved wrinkles, texture and elasticity.
- They are injected, not heated, so there is no pigment risk and they suit all skin tones.
References & sources
- Lampridou S, et al. The Effectiveness of Polynucleotides in Esthetic Medicine: A Systematic Review. J Cosmet Dermatol. 2024;24(2):e16721.
- Palmieri A, et al. Effect of biostimulation on oral fibroblast: a pilot study. J Biol Regul Homeost Agents. 2017;31(4 Suppl 2):139-145.
- Rejuran / PharmaResearch: product range information, pharmaresearch.com.
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Explore FAQs on Polynucleotides (Rejuran)
Find answers to common questions about Polynucleotides (Rejuran).
Short fragments of purified DNA, in Rejuran's case from salmon, that are highly compatible with skin. Injected in, they help the skin hold water, calm inflammation and support collagen.
No. It improves the quality of the skin itself rather than adding structural volume. It is better thought of as a bio-remodelling or skin-booster treatment.
Skin quality, elasticity and fine lines, with specific versions for the under-eye area and for scarring.
Yes. It is injected rather than heated, so there is no pigment risk, and its calming action can suit post-inflammatory skin. It is suitable for all skin tones.
Usually around three sessions a few weeks apart, followed by maintenance to keep the result.
Usually mild: small bumps, redness or slight swelling that settle within a day or two.
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