Are polynucleotides the same as dermal fillers?

No. Polynucleotides do not add volume or change facial structure. Instead, they work biologically by stimulating repair processes, calming inflammation, and improving skin quality over time. If your concern is skin fragility, texture issues, or inflammation rather than volume loss, regenerative treatments are often more appropriate than fillers.

How are polynucleotides different from PRP or skin boosters?

PRP uses your own blood-derived growth factors, while skin boosters primarily focus on hydration. Polynucleotides act directly on fibroblasts to promote natural tissue regeneration and anti-inflammatory repair. They are particularly valuable when the skin barrier is compromised or chronically inflamed.

Which areas of the face and body can be treated?

Polynucleotides are commonly used on the face, under the eyes, neck, décolletage, and areas with scarring or stretch marks. They are also used on the scalp for hair thinning. Delicate areas respond especially well because the treatment strengthens tissue rather than weighing it down.

Will the treatment look obvious or change how I look?

No. Polynucleotides do not create puffiness or alter facial shape. Improvements are subtle and progressive, focusing on skin quality rather than visible “work.” The goal is healthier, calmer, more resilient skin that still looks like you.

Is there downtime, and how many sessions will I need?

Downtime is minimal — temporary redness, swelling, small blebs, or mild bruising usually resolve within 1 to 2 days. A course of treatments is recommended to build regenerative change, followed by maintenance sessions, with timing guided by how your skin responds rather than a one-size-fits-all protocol.

Polynucleotides

Restore and revive your skin from within with polynucleotides. At Dr Bhavin Garara’s clinic, this regenerative treatment repairs damaged tissue, calms inflammation, and improves skin quality at a cellular level — strengthening and rebuilding your skin rather than masking the signs of ageing.

What are polynucleotides?

Restore skin strength and resilience

Polynucleotides are advanced regenerative injectables that improve skin quality by stimulating repair at a cellular level. Often referred to as PDRN serums, they are composed of purified DNA fragments that signal your skin to regenerate, reduce inflammation, and strengthen its structure from within. Rather than adding volume or altering shape, they focus on restoring resilience, hydration, and elasticity. Dr Garara uses polynucleotides thoughtfully as part of a bespoke treatment plan, selected only when regenerative repair is the right path for your skin.

Conditions

Polynucleotides treat:

Fine lines and early signs of ageingDull, dehydrated, or fatigued skinInflammation-prone conditions such as rosaceaAcne scarring and post-inflammatory marksSun damage and uneven pigmentationFragile or thinning skin around the eyes and mouthStretch marks and textural irregularitiesHair thinning and early alopecia

Quick Overview

Treatment at a Glance

Key facts about this procedure to help you understand what to expect before, during, and after your treatment.

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Treatment time

20 - 40 minutes

Recovery time

24 - 48 hours mild redness or blebs

Anaesthesia

Topical anaesthetic

Results duration

6 - 9 months

Sessions needed

Course of treatments, then maintenance

Aftercare

No make-up for 12 hours. Avoid heat and exercise for several days

How It Works

How do polynucleotides work?

Polynucleotides work by stimulating your skin’s natural repair processes. They are made from purified DNA fragments that communicate with fibroblasts, the cells responsible for producing collagen and elastin. This signalling encourages tissue regeneration, improves hydration, and reduces cellular inflammation. As inflammation reduces and collagen production increases, the skin becomes thicker, stronger, and more resilient. Because the process is biological rather than mechanical, improvements develop gradually as your skin repairs and renews from within.

Benefits of Treatments

The Real Benefits of Choosing Our Cosmetic Solutions

Supports skin repair and regeneration at a cellular level

Calms inflammation and reduces oxidative stress

Improves skin elasticity, hydration, and overall resilience

Enhances skin quality without adding volume or altering shape

Suitable for delicate and sensitive areas, including the under-eyes

Minimal downtime with a strong safety profile

Complements other aesthetic and regenerative treatments

Promotes gradual, natural-looking improvement over time

What to expect from polynucleotides with Dr Garara

Consultation: Your consultation with Dr Garara is detailed and personalised. You’ll begin by discussing your concerns, medical history, skin behaviour, and previous treatments. He will then assess your skin quality, elasticity, inflammation levels, and structural support, and examine delicate areas like the under-eyes and perioral skin closely. You’ll learn how polynucleotides work biologically, what results are realistic, and whether regenerative repair is appropriate for you.

Treatment: Your skin is first cleansed thoroughly, and clinical photographs may be taken for documentation. A topical anaesthetic is applied and left to take effect. Once prepared, Dr Garara carefully maps precise injection points and, using a fine needle, places small droplets of polynucleotides into the dermis, creating tiny, controlled blebs that settle within hours. In some areas, a blunt cannula may be used to evenly distribute the product.

Recovery: After your treatment, you may notice mild redness, small raised blebs, slight swelling, or pinpoint bruising at the injection sites. These effects are expected and typically settle within 24 to 48 hours, with the tiny blebs flattening within a few hours. You should avoid make-up for at least 12 hours and minimise heat exposure, exercise, and active skincare for several days.

Results: Because polynucleotides stimulate cellular repair, results develop gradually rather than instantly. You may begin to notice subtle improvements in skin texture, hydration, and resilience within 2 to 3 weeks as inflammation reduces and regeneration begins. Skin quality continues to improve over subsequent weeks, and results last 6 to 9 months depending on your skin health, lifestyle, and ageing. Maintenance treatments may be recommended.